Hydroxyethyl starch 200/0.5 induces more renal macrophage infiltration than hydroxyethyl starch 130/0.42 in an isolated renal perfusion model
نویسندگان
چکیده
منابع مشابه
Nephrotoxicity of hydroxyethyl starch solution.
Editor—Delayed graft function (DGF) after transplan-tation of cadaver kidneys is associated with poorer subsequent graft survival. 1 Fluid management during the donor operation can significantly modify the risk of DGF. Thus, in a blinded randomized trial of 69 kidney transplants from brain-dead donors, 2 volume loading with a mean of 2100 ml hydroxyethyl starch (HES) increased the incidence of ...
متن کاملHydroxyethyl starch in severe sepsis: end of starch era?
CITATION Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Åneman A, Madsen KR, Møller MH, Elkjær JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Søe-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kjældgaard AL, Fabritius ML, Mondrup F, Pott FC, Møller TP, Winkel P, Wetterslev J; 6S Trial Group; Scan...
متن کاملHydroxyethyl starch in patients with trauma.
Editor—The Fluids in Resuscitation of Severe Trauma (FIRST) randomized trial conducted by James and colleagues compared hydroxyethyl starch (HES) 130/0.4 with 0.9% saline in the resuscitation of 115 patients with severe blunt or penetrating trauma at a single centre in South Africa. In blunt trauma, which accounts for 86–97% of all traumatic injuries in Europe, 3 no differences were found betwe...
متن کاملPharmacokinetics of hydroxyethyl starch in normal subjects.
To determine the elimination of high-molecular-weight hydroxyethyl starch (HES, Mw 450,000) in normal subjects, ten volunteers were given 500 ml 6% HES solution by intravenous infusion, and serial blood and urine samples were collected for nonglucose total carbohydrate determination. On the average, 46 and 64 per cent of the dose was excreted in the urine within two and eight days, respectively...
متن کاملHydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model
INTRODUCTION The aim of the study was to evaluate some of the underlying pathomechanisms of hydroxyethylstarch (HES) induced adverse effects on renal function using 24 porcine kidneys in an isolated perfusion model over six hours. METHODS Infusion of either 10% HES 200/0.5, 6% HES 130/0.42 or Ringer's lactate (RL) was performed to achieve an haematocrit of 20% in eight kidneys from four anima...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Critical Care
سال: 2008
ISSN: 1364-8535
DOI: 10.1186/cc6453